The New Penicillins in Endocarditis.

Prevention of Bacterial Endocarditis in Dentistry: the New Guidline

The American Heart Association (AHA) has provided new guidelines for infective endocarditis prophylaxis in dentistry. In this paper, written for dentists, major changes in the updated recommendations which dentists should be aware have been discussed. These recommendations address the impact of oral hygiene and type of dental procedures on high-risk patients, risk of adverse reactions of antibi...

Treatment of Bacterial Endocarditis with Oral Penicillins.

Endocarditis caused by relatively penicillin-resistant Stomatococcus mucilaginosus.

We report a case of Stomatococcus mucilaginosus endocarditis in which the isolate was relatively resistant to penicillins and cephalothin. The patient was treated successfully with vancomycin and valve replacement.

Progress in bacterial endocarditis.

Introduction The success of penicillin in bacterial endocarditis has created new problems for the clinician. These include the need to make an early diagnosis, the choice of antibiotic, the difficulty of telling whether infection has been eliminated, and the prognosis when infection has been controlled. Moreover, the proper use of antibiotics to prevent bacterial endocarditis is of great import...

JAC pp519-22 MW3063

Enterococci are isolated from 10–20% of cases of bacterial endocarditis and therapy generally consists of a combination of a penicillin or vancomycin plus an aminoglycoside. For the penicillins, data suggest that serum concentrations should be maintained above the MIC throughout the dosing interval to prevent the loss of efficacy, since no post-antibiotic effect has been observed for these agen...